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The key moment in the history of the developer was the year of when it was awarded the first prestigious award in the field of gambling.
Endorphina software products have a high level of quality, which is confirmed by iTech Labs tests. The company regularly participates in exhibitions in the field of gambling, including the iGaming Super Show in Amsterdam and many others.
In , the company entered into an agreement with Iforium. Most of Endorphina gaming machines are equipped with 5 reels.
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They are produced and stored in the pituitary gland. The classification of molecules as endorphins is based on their pharmacological activity, as opposed to a specific chemical formulation.
Endorphins may also produce a feeling of euphoria very similar to that produced by other opioids. Opioid peptides in the brain were first discovered in by two independent groups of investigators: John Hughes and Hans Kosterlitz.
Rabi Simantov and Solomon H. Snyder isolated morphine-like peptides from calf brain. Simon , who independently discovered opioid receptors, would later term these peptides as endorphins.
In addition, they found that it is completely removed from opiate receptors by naloxone , an identified morphine antagonist.
Studies have subsequently distinguished between enkephalins, endorphins, and endogenously-produced morphine,   which is not a peptide.
Opioid peptides are classified based on their precursor propeptide: all endorphins are synthesized from the precursor proopiomelanocortin POMC , encoded by proenkephalin A, and dynorphins encoded by pre-dynorphin.
Thus, endorphin is a contraction of 'endo genous mo rphin' morphin being the old spelling of morphine. Endorphin precursors are primarily produced in the pituitary gland.
Endorphins are released from the pituitary gland, typically in response to pain, and can act in both the central nervous system CNS and the peripheral nervous system PNS.
In turn, inhibition of GABA increases the production and release of dopamine , a neurotransmitter associated with pleasure. Endorphins play a major role in the body's inhibitory response to pain.
For example, endorphin release is responsible for producing the euphoric state in cases such as runner's high, sex , orgasm , listening to music, and eating appetizing food such as chocolate.
Endorphin production can also be triggered by vigorous aerobic exercise. Regular intense exercise may cause the brain to downregulate the production of endorphins in periods of rest to maintain homeostasis , causing a person to exercise more intensely in order to receive the same feeling.
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It's been theorized that problems with endorphin production or the binding process may be responsible for clinical depression or sudden shifts in emotions.
Some people who engage in self-hurting behaviors may do so in part to feel the feelings of euphoria and emotional isolation that can -- for them -- be prompted by controlled amounts of self-inflicted pain.
Endorphins may also be responsible for heightened states of rage or anxiety. If your endorphins overdo their job or the hypothalamus misreads the endorphin cue, you could be flooded with "fight-or-flight" hormones at the slightest hint of trouble or worry.
Endorphins affect us like codeine or morphine do, but without the addiction. Regular users of opiates generally aren't models of emotional stability, and steady, controlled endorphin release is something of a pipe dream.
Making matters worse, some of us have brains that act like ambitious drug dealers, and others of us only dabble now and then.
This variation can help explain why one person reacts differently from another to the same stimulus.
Endorphins have a leg up on opiates, however. Endorphins may be responsible for the "placebo effect," owing to the real response of endorphin-release prompted by a tricked hypothalamus, creating a sense of well-being after consuming a much-hyped sugar pill, or even after simply anticipating something pleasurable.
When endorphins lock into the opioid receptors, they are almost immediately broken down by enzymes, allowing them to be recycled and reused down the road.
However, when similarly shaped but chemically different opiates lock into these same receptors, they are resistant to the enzymes and continue reactivating the receptors over and over, extending the "high" and increasing euphoric feelings, as well as the likelihood of dependence.
Many things can trigger the release of endorphins. Though many triggers are known to exist which we'll discuss in a moment , the primary triggers are stress and pain.
When your hypothalamus detects pain, it issues several orders, one of them being, "Quit telling me it hurts! The hypothalamus is the command-and-control center of your endocrine system.